Article
Properties of single NMDA receptor channels in human dentate gyrus granule cells.
The Journal of physiology - 1 Jul 1999
Lieberman D N, Mody I
Abstract excerpt
1. Cell-attached single-channel recordings of NMDA channels were carried out in human dentate gyrus granule cells acutely dissociated from slices prepared from hippocampi surgically removed for the treatment of temporal lobe epilepsy (TLE). The channels were activated by L-aspartate (250-500 nM) in the presence of saturating glycine (8 microM). 2. The main conductance was 51 +/- 3 pS. In ten of thirty granule...
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