Effect of subunit composition and Liddle's syndrome mutations on biosynthesis of ENaC.

Abstract excerpt

The epithelial Na+ channel (ENaC) is comprised of three homologous subunits: alpha, beta, and gamma, all of which are required for formation of the fully functional channel. This channel is responsible for salt reabsorption in the kidney, the airway, and the large bowel. Mutations in ENaC can cause human disease by increasing channel function in Liddle's syndrome, a form of hereditary hypertension, or by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to COS Cells
• Share to Epithelial Sodium Channels
• Share to Hypertension