Article
Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.
International journal of pancreatology : official journal of the International Association of Pancreatology - 1 Apr 1999
Yatsuoka T, Furukawa T, Abe T, Yokoyama T, Sunamura M, Kobari M, Matsuno S, Horii A
Abstract excerpt
CONCLUSION: Abnormality of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 appears to play a limited role in pancreatic ductal carcinogenesis. BACKGROUND: Recently, a human G/T-specific TDG gene was identified. This protein acts in a system correcting G/T mispairs to G/C pairs. TDG was mapped to chromosome bands 12q22-q24.1, one of the regions frequently lost in pancreatic cancer. Therefore, there is the...
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