Article
Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations.
Carcinogenesis - 1 Jun 1999
Shinmura K, Kohno T, Takahashi M, Sasaki A, Ochiai A, Guilford P, Hunter A, Reeve A E, Sugimura H, Yamaguchi N, Yokota J
Abstract excerpt
Gastric cancer frequently occurs in family members with hereditary non-polyposis colorectal cancer (HNPCC) and Li-Fraumeni syndrome (LFS) and germline E-cadherin mutations were recently identified in a subset of familial gastric cancers. Thus, families with an aggregation of gastric cancers were recruited by reviewing the genealogical trees of 3632 patients with gastric cancer. The criteria for recruiting such...
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