Article
Human leucocyte antigen class II associations in chronic idiopathic urticaria.
The British journal of dermatology - 1 May 1999
O'Donnell B F, O'Neill C M, Francis D M, Niimi N, Barr R M, Barlow R J, Kobza Black A, Welsh K I, Greaves M W
Abstract excerpt
The major histocompatibility complex (MHC) acts as a marker for self during T-cell ontogeny and is associated with the pathogenesis of many autoimmune diseases. Recent investigations have shown about 30% of patients with chronic idiopathic urticaria (CIU) have IgG autoantibodies against the high-affinity IgE receptor, FcepsilonRI, or IgE. A link between MHC class II alleles and CIU has not been reported...
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