Article
Association between chronic cutaneous lupus erythematosus and HLA class II alleles.
Human immunology - 1 Dec 1994
Fischer G F, Pickl W F, Faé I, Anegg B, Milota S, Volc-Platzer B
Abstract excerpt
CCLE, a disease entity at the benign end of the lupus spectrum, is characterized by marked photosensitivity and skin lesions in sun-exposed areas. The histopathology of lesions resembles hypersensitivity type IV reactions. We have asked whether an association between class II alleles and CCLE exists. RFLP analysis of HLA-DQA genes revealed a Taq I HLA-DQA1 allelic restriction fragment overrepresented in a group...
Topics
- Alleles
- HLA-D Antigens
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Lupus Erythematosus, Discoid
- Oligonucleotide Probes