Article
Mutators and sex in bacteria: conflict between adaptive strategies.
Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 2000
Tenaillon O, Le Nagard H, Godelle B, Taddei F
Abstract excerpt
Bacterial mutation rates can increase and produce genetic novelty, as shown by in vitro and in silico experiments. Despite the cost due to a heavy deleterious mutation load, mutator alleles, which increase the mutation rate, can spread in asexual populations during adaptation because they remain associated with the rare favorable mutations they generate. This indirect selection for a genetic system generating...
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