Article
The DD genotype of the angiotensin converting enzyme gene is negatively associated with right ventricular hypertrophy in male patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine - 1 Jun 1999
van Suylen R J, Wouters E F, Pennings H J, Cheriex E C, van Pol P E, Ambergen A W, Vermelis A M, Daemen M J
Abstract excerpt
The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T polymorphism in the angiotensinogen gene, the 287-base-pair insertion (I)/deletion (D)...
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