Article
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Feb 1999
Haagsma C J, Blom H J, van Riel P L, van't Hof M A, Giesendorf B A, van Oppenraaij-Emmerzaal D, van de Putte L B
Abstract excerpt
OBJECTIVE: To study the influence of sulphasalazine (SSZ), methotrexate (MTX), and the combination (COMBI) of both on plasma homocysteine and to study the relation between plasma homocysteine and their clinical effects. METHODS: 105 patients with early rheumatoid arthritis (RA) were randomised between SSZ (2-3 g/day), MTX (7.5-15 mg/week), and the COMBI (same dose range) and evaluated double blindly during 52...
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