Article
Synthesis of the quinoline-linked triazolopyrimidine analogues and their interactions with the recombinant tobacco acetolactate synthase.
Biochemical and biophysical research communications - 19 May 1999
Namgoong S K, Lee H J, Kim Y S, Shin J H, Che J K, Jang D Y, Kim G S, Yoo J W, Kang M K, Kil M W, Choi J D, Chang S I
Abstract excerpt
Acetolactate synthase (ALS) is the first common enzyme in the biosynthesis of L-leucine, L-isoleucine, and L-valine. Triazolopyrimidine sulfonamide (TP) is a mixed-type inhibitor of ALS with respect to both pyruvate and thiamine pyrophosphate. In this study, we synthesized new substituted quinoline-linked TP analogues and several TP analogues which contained either unsubstituted aminoquinolines or amino...
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