Article
High incidence of molecular defects of the CYP21 gene in patients with premature adrenarche.
The Journal of clinical endocrinology and metabolism - 1 May 1999
Dacou-Voutetakis C, Dracopoulou M
Abstract excerpt
On the basis of hormonal studies, the incidence of defective steroidogenesis in children with premature adrenarche (PA) in the various reports ranges from 0-54%. Molecular studies have not been reported to date. The aim of the present study was to search for defects in the CYP21 gene in children with PA and to detect possible correlations of the molecular defect to pertinent hormonal and clinical data. In 48...
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