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Article

Molecular defects of the CYP21 gene in Spanish girls with isolated precocious pubarche.

European journal of endocrinology - 1 Oct 2002

Potau N, Riqué S, Eduardo I, Marcos V, Ibañez L

Abstract excerpt

OBJECTIVE: To determine the frequency of mutant alleles in the CYP21 gene in Spanish girls presenting with precocious pubarche (PP) and to assess the relationships between genotype and endocrine-metabolic variables. DESIGN: Fifty-three unrelated girls with a history of PP (14 prepubertal, 8 pubertal and 31 postmenarcheal) and 35 controls were studied. METHODS: Genomic DNA was extracted from peripheral blood...

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Identifiers

PMID: 12370110
DOI: 10.1530/eje.0.1470485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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