Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermutation in pathogenic bacteria: frequent phase variation in meningococci is a phenotypic trait of a specialized mutator biotype.

Molecular cell - 1 Apr 1999

Bucci C, Lavitola A, Salvatore P, Del Giudice L, Massardo D R, Bruni C B, Alifano P

Abstract excerpt

Expression of serogroup B meningococcal capsular polysaccharide undergoes frequent phase variation involving reversible frameshift mutations within a homopolymeric repeat in the siaD gene. A high rate of phase variation is the consequence of a biochemical defect in methyl-directed mismatch repair...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Capsules
Share to DNA Repair
Share to DNA Restriction Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Neisseria meningitidis

Share to Restriction Mapping

Share to Site-Specific DNA-Methyltransferase (Adenine-Specific)

Share to Transformation, Genetic

Source

Identifiers

PMID: 10230396
DOI: 10.1016/s1097-2765(00)80471-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10230396-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermutation in pathogenic bacteria: frequent phase variation in meningococci is a phenotypic trait of a specialized mutator biotype.PMID 10230396Read ↗

Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic NeisseriaSemantic proximity Read ↗

Mismatch repair and the regulation of phase variation in Neisseria meningitidis.Semantic proximity Read ↗

Mutator clones of Neisseria meningitidis in epidemic serogroup A disease.Semantic proximity Read ↗

Involvement of genes of genome maintenance in the regulation of phase variation frequencies in Neisseria meningitidisSemantic proximity Read ↗

Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulenceSemantic proximity Read ↗

Phasevarions of bacterial pathogens – phase-variable epigenetic regulators evolving from restriction–modification systemsSemantic proximity Read ↗

The streptococcal phase-variable Type I Restriction-Modification system SsuCC20p dictates the methylome of <i>Streptococcus suis</i> and impacts virulenceSemantic proximity Read ↗

A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44.Semantic proximity Read ↗

Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial PathogensSemantic proximity Read ↗

Phasevarions mediate random switching of gene expression in pathogenic Neisseria.Semantic proximity Read ↗

Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distributionSemantic proximity Read ↗

The streptococcal phase-variable type I restriction modification system SsuCC20p dictates the methylome of Streptococcus suis impacting the transcriptome and virulence in a zebrafish larvae infection modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.