Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha 1-antichymotrypsin mutations in patients with chronic obstructive pulmonary disease.

Disease markers - 1 Feb 1998

Sandford A J, Chagani T, Weir T D, Paré P D

Abstract excerpt

Mutations in the alpha 1-antichymotrypsin gene have been described which result in reduced levels of alpha 1-antichymotrypsin in the serum. Previous studies have suggested that two of these mutations (Pro227-->Ala and Leu55-->Pro) predispose to chronic obstructive pulmonary disease (COPD). We have investigated the prevalence of these mutations in 168 COPD patients and 61 controls without airflow obstruction. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to alpha 1-Antichymotrypsin
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Diseases, Obstructive

Share to Mutation

Share to Proline

Source

Identifiers

PMID: 9553741
DOI: 10.1155/1998/867620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Alpha 1-antichymotrypsin mutations in patients with chronic obstructive pulmonary disease.PMID 9553741Read ↗

Association between alpha-1-antichymotrypsin polymorphism and susceptibility to chronic obstructive pulmonary disease.Semantic proximity Read ↗

Association of alpha(1)-antichymotrypsin deficiency with milder lung disease in patients with cystic fibrosis.Semantic proximity Read ↗

A Leucine-to-Proline Substitution Causes a Defective α1-Antichymotrypsin Allele Associated with Familial Obstructive Lung DiseaseSemantic proximity Read ↗

A novel polymorphism (471C-->T) in alpha-1-antitrypsin in a patient with asthma.Semantic proximity Read ↗

Positive association between two polymorphic sites (+134 insA/delA and G198T) of the endothelin-1 gene and chronic obstructive pulmonary disease. A case-control study.Semantic proximity Read ↗

Mutation in the 3' region of the alpha-1-antitrypsin gene and chronic obstructive pulmonary disease.Semantic proximity Read ↗

alpha1-antitrypsin genotypes and the acute-phase response to open heart surgery.Semantic proximity Read ↗

alpha(1)-Antichymotrypsin deficiency associated with liver cirrhosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.