Aggregation of M3 (E376D) variant of alpha1- antitrypsin.

doi:10.1038/s41598-020-64860-1

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Article

Aggregation of M3 (E376D) variant of alpha1- antitrypsin.

Scientific reports - 19 May 2020

Bashir Arif, Hazari Younis, Pal Debnath, Maity Dibyajyoti, Bashir Samirul, Singh Laishram Rajendrakumar, Shah Naveed Nazir, Fazili Khalid Majid

Abstract excerpt

Alpha1-antitrypsin (α1AT) is an abundant serine-protease inhibitor in circulation. It has an important role in neutralizing the neutrophil elastase activity. Different pathogenic point mutations like Z(E342K)-α1AT have been implicated in the development of liver cirrhosis and Chronic Obstructive Pulmonary Disease (COPD), the latter being a cluster of progressive lung diseases including chronic bronchitis and...

Topics

Amino Acid Substitution
Case-Control Studies
Circular Dichroism
Dynamic Light Scattering
Female
Genotype
Humans
Male
Molecular Dynamics Simulation
Protein Aggregates
Pulmonary Disease, Chronic Obstructive
Trypsin
alpha 1-Antitrypsin

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Identifiers

PMID: 32427833
DOI: 10.1038/s41598-020-64860-1
PMCID: PMC7237413

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