Article
Lack of sex-specific effects on the association between angiotensin-converting enzyme gene polymorphism and hypertension in Japanese.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 1999
Sugiyama T, Morita H, Kato N, Kurihara H, Yamori Y, Yazaki Y
Abstract excerpt
Although several studies of molecular genetics have investigated the relevance of the ACE gene to essential hypertension, the relationship remains controversial. Some studies have recently implicated sex-specificity of this candidate gene in hypertension genetics; that is, significant linkage and association were observed in men but not in women in Caucasian populations. In particular, a male-specific association...
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