Article
Sensorineural hearing loss and the 1555G mitochondrial DNA mutation.
Acta oto-laryngologica - 1 Jan 1999
Hutchin T
Abstract excerpt
Recent studies have identified a mitochondrial DNA mutation (1555G) which causes sensorineural hearing loss (SNHL). In many cases deafness follows exposure to aminoglycoside antibiotics, the 1555G mutation sensitizing the inner ear to these drugs. The 50 cases reported to date are discussed, as are the possible mechanisms behind the pathogenesis of this mutation. This finding in families from a wide range of...
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