Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation.

doi:10.1097/00005537-199704000-00011

Back to search

Article

Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation.

The Laryngoscope - 1 Apr 1997

Usami S, Abe S, Kasai M, Shinkawa H, Moeller B, Kenyon J B, Kimberling W J

Abstract excerpt

Five Japanese families showing aminoglycoside-induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects. One hundred American control subjects did not show any evidence of the mutation at nucleotide 155...

Topics

Aminoglycosides
Asian People
Audiometry
Genetic Predisposition to Disease
Hearing Loss, Sensorineural
Humans
Japan
Pedigree
Point Mutation
RNA
RNA, Mitochondrial
Vestibular Function Tests

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.