Article
Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation.
The Laryngoscope - 1 Apr 1997
Usami S, Abe S, Kasai M, Shinkawa H, Moeller B, Kenyon J B, Kimberling W J
Abstract excerpt
Five Japanese families showing aminoglycoside-induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects. One hundred American control subjects did not show any evidence of the mutation at nucleotide 1555, suggesting that the 1555 A-->G (A1555G) mitochondrial mutation may be found more frequently among populations in the...
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