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Article

High Specificity of Mullerian-Inhibiting Substance Signaling in Vivo*

1 May 1999

Abstract excerpt

Female transgenic mice that ectopically express high levels of human Müllerian-inhibiting substance (hMIS) under the control of the mouse metallothionein (MT) promoter lack a uterus, oviducts, and ovaries. The loss of the uterus and oviducts is consistent with the known activities for MIS. However, it is not clear if the loss of the ovaries in these transgenic females is caused by interactions of MIS with its...

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Identifiers

PMID: 10218958
DOI: 10.1210/endo.140.5.6705

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