Article
Prenatal fragile X detection using cytoplasmic and nuclear-specific monoclonal antibodies.
American journal of medical genetics - 2 Apr 1999
Jenkins E C, Wen G Y, Kim K S, Zhong N, Sapienza V J, Hong H, Chen J, Li S Y, Houck G E, Ding X, Nolin S L, Dobkin C S, Brown W T
Abstract excerpt
We have been carrying out studies aimed at improving prenatal detection of the fragile X chromosome/mutation. Our current protocol requires a turnaround time (TAT) of several days. In an attempt to reduce the TAT, we have turned to the use of monoclonal antibodies (mAbs). Monoclonal antibody 1A1 (provided by Dr. Mandel of INSERM) immunostaining was performed according to a modified three-step immunocytochemical...
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