Fragile X induction systems in CVS cultures: effect on cytogenetic, PCR, and genomic Southern Blot DNA analyses of the FMR-1 gene.

doi:10.1002/ajmg.1320510426

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Article

Fragile X induction systems in CVS cultures: effect on cytogenetic, PCR, and genomic Southern Blot DNA analyses of the FMR-1 gene.

American journal of medical genetics - 15 Jul 1994

Jenkins E C, Morys I, Henderson J, Genovese M, Carter M, Li S Y, Houck G E, Ding X, Stark-Houck S L, Dobkin C S

Abstract excerpt

Low fragile X frequencies have been commonly observed in chorionic villus sample (CVS) cultures, compared to subsequent analysis in whole blood or products of conception (POC). To investigate possible mechanisms for this effect, CVS cultures from a previously identified fragile X positive male, w...

Topics

Blotting, Southern
Cells, Cultured
Chorionic Villi
Chorionic Villi Sampling
Chromosome Banding
Chromosome Fragility
Culture Techniques
DNA
DNA Probes
Dinucleoside Phosphates
False Negative Reactions
Female
Fetus
Floxuridine

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fragile X Syndrome

Gene Expression Regulation

Gene Frequency

Humans

Source

Open in PubMed

Identifiers

PMID: 7943013
DOI: 10.1002/ajmg.1320510426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7943013-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.