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The Role of Pr55 gag in the Annealing of tRNA 3 Lys to Human Immunodeficiency Virus Type 1 Genomic RNA

1 May 1999

Abstract excerpt

During human immunodeficiency virus type 1 (HIV-1) assembly, the primer tRNA for the reverse transcriptase-catalyzed synthesis of minus-strand strong-stop cDNA, tRNA3Lys, is selectively packaged into the virus and annealed onto the primer binding site on the RNA genome. Annealing of tRNA3Lys in HIV-1 is independent of polyprotein processing and is facilitated in vitro by p7 nucleocapsid (NCp7). We have previously...

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PMID: 10196352
DOI: 10.1128/jvi.73.5.4485-4488.1999

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Related research

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The Role of Pr55 gag in the Annealing of tRNA 3 Lys to Human Immunodeficiency Virus Type 1 Genomic RNAPMID 10196352Read ↗

The role of nucleocapsid and U5 stem/A-rich loop sequences in tRNA(3Lys) genomic placement and initiation of reverse transcription in human immunodeficiency virus type 1.Semantic proximity Read ↗

Role of Pr160gag-pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particlesSemantic proximity Read ↗

Correlation between tRNALys3 aminoacylation and its incorporation into HIV-1.Semantic proximity Read ↗

Molecular mimicry of human tRNALys anti-codon domain by HIV-1 RNA genome facilitates tRNA primer annealing.Semantic proximity Read ↗

Forced selection of tRNA(Glu) reveals the importance of two adenosine-rich RNA loops within the U5-PBS for SIV(smmPBj) replication.Semantic proximity Read ↗

Effects of modifying the tRNA(3Lys) anticodon on the initiation of human immunodeficiency virus type 1 reverse transcription.Semantic proximity Read ↗

The Interaction of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleocapsid Inhibits tRNA <sub>3</sub> <sup>Lys</sup> Annealing to Viral RNASemantic proximity Read ↗

Primer tRNA3Lys on the viral genome exists in unextended and two-base extended forms within mature human immunodeficiency virus type 1Semantic proximity Read ↗

Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication.Semantic proximity Read ↗

Profiling non-lysyl tRNAs in HIV-1Semantic proximity Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

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