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Article

Evaluation of the stability and immunogenicity of autoclaved and nonautoclaved preparations of a vaccine against American tegumentary leishmaniasis.

Vaccine - 5 Mar 1999

De Luca P M, Mayrink W, Alves C R, Coutinho S G, Oliveira M P, Bertho A L, Toledo V P, Costa C A, Genaro O, Mendonça S C

Abstract excerpt

This study was designed to evaluate the immunogenicity of autoclaved and nonautoclaved preparations of a vaccine composed of whole antigens from killed promastigotes of Leishmania amazonensis. Leishmanin skin-test (LST)-negative volunteers were immunized with either autoclaved or nonautoclaved vaccine preparations (32 and 36 subjects, respectively) that had been maintained at 4 degrees C for one year before the...

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Identifiers

PMID: 10195630
DOI: 10.1016/s0264-410x(98)00338-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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