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Article

Characteristics of small breast and/or ovarian cancer families with germline mutations in BRCA1 and BRCA2.

British journal of cancer - 1 Mar 1999

Ligtenberg M J, Hogervorst F B, Willems H W, Arts P J, Brink G, Hageman S, Bosgoed E A, Van der Looij E, Rookus M A, Devilee P, Vos E M, Wigbout G, Struycken P M, Menko F H, Rutgers E J, Hoefsloot E H, Mariman E C, Brunner H G, Van 't Veer L J

Abstract excerpt

For families with a small number of cases of breast and/or ovarian cancer, limited data are available to predict the likelihood of genetic predisposition due to mutations in BRCA1 or BRCA2. In 104 families with three or more affected individuals (average 3.8) seeking counselling at family cancer clinics, mutation analysis was performed in the open reading frame of BRCA1 and BRCA2 by the protein truncation test...

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Share to BRCA2 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10188893
DOI: 10.1038/sj.bjc.6690235
PMCID: PMC2362698

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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