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Article

High-frequency, in vitro reversible switching of Candida lusitaniae clinical isolates from amphotericin B susceptibility to resistance.

Antimicrobial agents and chemotherapy - 1 Apr 1999

Yoon S A, Vazquez J A, Steffan P E, Sobel J D, Akins R A

Abstract excerpt

Recent studies have revealed an increase in the incidence of serious infections caused by non-albicans Candida species. Candida lusitaniae is of special interest because of its sporadic resistance to amphotericin B (AmB). The present in vitro study demonstrated that, unlike other Candida species, C. lusitaniae isolates frequently generated AmB-resistant lineages form previously susceptible colonies. Cells...

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Identifiers

PMID: 10103188
DOI: 10.1128/AAC.43.4.836
PMCID: PMC89214

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