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Article

Pregnenolone esterification in Saccharomyces cerevisiae. A potential detoxification mechanism.

European journal of biochemistry - 1 Apr 1999

Cauet G, Degryse E, Ledoux C, Spagnoli R, Achstetter T

Abstract excerpt

While studying the effect of steroids on the growth of the yeast Saccharomyces cerevisiae, we found that pregnenolone was converted into the acetate ester. This reaction was identified as a transfer of the acetyl group from acetyl-CoA to the 3beta-hydroxyl group of pregnenolone. The corresponding enzyme, acetyl-CoA:pregnenolone acetyltransferase (APAT) is specific for Delta5- or Delta4-3beta-hydroxysteroids and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10103065
DOI: 10.1046/j.1432-1327.1999.00282.x

Genes

ATF2
ATF1
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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