Mutants of Kluyveromyces lactis with altered protein glycosylation are affected in cell wall morphogenesis.

doi:10.1016/s0923-2508(99)80041-2

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Article

Mutants of Kluyveromyces lactis with altered protein glycosylation are affected in cell wall morphogenesis.

Research in microbiology - 1 Jan 2000

Uccelletti D, Farina F, Morlupi A, Palleschi C

Abstract excerpt

We isolated spontaneous mutants resistant to sodium orthovanadate in the biotechnologically significant yeast Kluyveromyces lactis. Resistance behaved as a recessive character in all mutants analyzed. Four genes were defined by complementation analysis, from vga1 to vga4. These mutants showed defects in N-linked as well as O-linked glycosylation processes. In addition, the mutants exhibited sensitivity to the...

Topics

Cell Wall
Chitin
Drug Resistance, Microbial
Genes, Fungal
Genetic Complementation Test
Glycosylation
Immunoblotting
Kluyveromyces
Microscopy, Fluorescence
Mutation
Vanadates

Source

Open in PubMed

Identifiers

PMID: 10096129
DOI: 10.1016/s0923-2508(99)80041-2

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