Article
Natural killer cell-mediated recognition of human trophoblast.
Seminars in cancer biology - 1 Feb 1999
Biassoni R, Bottino C, Millo R, Moretta L, Moretta A
Abstract excerpt
Large numbers of natural killer cells are present within the maternal decidua close to the extravillous trophoblast cells. Most of these natural killer cells express high levels of inhibitory NK receptors (KIR) specific for HLA class I molecules. Since trophoblast cells only express HLA-C and HLA-G, the KIR expressed by decidual NK cells can only recognize these HLA class I molecules in order to avoid NK-mediated...
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