Article
New insights into the evolutionary rate of hepatitis B virus at different biological scales.
Journal of virology - 1 Apr 2015
Lin You-Yu, Liu Chieh, Chien Wei-Hung, Wu Li-Ling, Tao Yong, Wu Dafei, Lu Xuemei, Hsieh Chia-Hung, Chen Pei-Jer, Wang Hurng-Yi, Kao Jia-Horng, Chen Ding-Shinn
Abstract excerpt
UNLABELLED: The evolutionary rates of hepatitis B virus (HBV) estimated using contemporary sequences are 10(2) to 10(4) times higher than those derived from archaeological and genetic evidence. This discrepancy makes the origin of HBV and the time scale of its spread, both of which are critical for studying the burden of HBV pathogenicity, largely unresolved. To evaluate whether the dual demands (i.e., adaptation...
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