Article
Two naturally occurring amino acid substitutions of the 5-HT2A receptor: similar prevalence in patients with seasonal affective disorder and controls.
Biological psychiatry - 15 Dec 1996
Ozaki N, Rosenthal N E, Pesonen U, Lappalainen J, Feldman-Naim S, Schwartz P J, Turner E H, Goldman D
Abstract excerpt
We screened the 5-HT2A receptor gene coding region in 50 patients with seasonal affective disorder (SAD) using a single strand conformational polymorphism analysis and estimated the frequencies of two synonymous and two non-synonymous substitutions we detected in 70 Centre d'Etude du Polymorphism Humain (CEPH) population controls and 62 normal controls. Both of the amino acid substitutions: Ala447-Val447 and...
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