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Article

Starvation in yeast increases non-adaptive mutation.

Current genetics - 1 Mar 1999

Marini A, Matmati N, Morpurgo G

Abstract excerpt

The frequency of reversion in a histidine-requiring mutant of Saccharomyces cerevisiae increases about ten-fold in stationary cells during histidine starvation. Histidine starvation enhances a similar frequency of reversion in a tryptophan-requiring mutant. Starvation, therefore, enhances mutation frequencies in a non-adaptive manner. The base analogue 6-N-hydroxylaminopurine (HAP) added prior to plating on...

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PMID: 10079325
DOI: 10.1007/s002940050435

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