Article
The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999
Lee J P, Palfrey H C, Bindokas V P, Ghadge G D, Ma L, Miller R J, Roos R P
Abstract excerpt
It has been reported that expression of familial amyotrophic lateral sclerosis (FALS)-associated mutant Cu/Zn superoxide dismutase-1 (SOD) induces apoptosis of neuronal cells in culture associated with an increase in reactive oxygen species. SOD recently has been shown to prevent calcineurin inactivation, initiating the present investigations examining the role of calcineurin in mutant SOD-induced cell death....
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