Article
Molecular exclusion of haemoglobin SD disease by prenatal diagnosis.
Prenatal diagnosis - 1 Jan 1999
Fodor F H, Eng C M
Abstract excerpt
The most common Hb D variant, Haemoglobin D (Hb D) Los Angeles is caused by a glutamic acid to glutamine substitution at codon 121 of the beta globin gene. Although asymptomatic in the heterozygous form, inheritance together with an Hb S allele can result in a severe disease similar to sickle-cell anaemia that is referred to as Hb SD disease. Prenatal diagnosis for Hb SD disease was requested by an at-risk couple...
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