Article
Inheritance of a mitochondrial DNA defect and impaired glucose tolerance in BHE/Cdb rats.
Diabetologia - 1 Jan 1999
Mathews C E, McGraw R A, Dean R, Berdanier C D
Abstract excerpt
As they age, BHE/Cdb rats develop impaired glucose tolerance. We hypothesized that this intolerance is associated with a previously reported base substitution in the mitochondrial genome. A new screening test was devised to identify animals with the mutation. These animals were bred to animals without the mutation. The progeny were then tested for the presence of the mutation and their glucose tolerance at 100...
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