Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants.

doi:10.1093/genetics/139.1.95

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Article

Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants.

Genetics - 1 Jan 1995

Di Como C J, Bose R, Arndt K T

Abstract excerpt

The Saccharomyces cerevisiae SIS2 gene was identified by its ability, when present on a high copy number plasmid, to increase dramatically the growth rate of sit4 mutants. SIT4 encodes a type 2A-related protein phosphatase that is required in late G1 for normal G1 cyclin expression and for bud initiation. Overexpression of SIS2, which contains an extremely acidic carboxyl terminal region, stimulated the rate of...

Topics

Amino Acid Sequence
Base Sequence
Cell Compartmentation
Cell Cycle
Cell Cycle Proteins
Cell Nucleus
Chromatin
Cyclins
DNA-Binding Proteins
Fungal Proteins
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Fungal

Genes, Fungal

Molecular Sequence Data

Mutation

Phosphoprotein Phosphatases

Protein Phosphatase 2

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 7705654
DOI: 10.1093/genetics/139.1.95
PMCID: PMC1206351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7705654-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants.PMID 7705654Read ↗

The SIT4 protein phosphatase functions in late G1 for progression into S phase.Semantic proximity Read ↗

Characterization of SIS1, a Saccharomyces cerevisiae homologue of bacterial dnaJ proteins.Semantic proximity Read ↗

The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase.Semantic proximity Read ↗

The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle.Semantic proximity Read ↗

Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.Semantic proximity Read ↗

The SIT4 protein phosphatase is required in late G1 for progression into S phase.Semantic proximity Read ↗

The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1.Semantic proximity Read ↗

Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase.Semantic proximity Read ↗

A genetic screen reveals a role for the late G1-specific transcription factor Swi4p in diverse cellular functions including cytokinesis.Semantic proximity Read ↗

Global gene expression analysis of fission yeast mutants impaired in Ser-2 phosphorylation of the RNA pol II carboxy terminal domain.Semantic proximity Read ↗

Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4.Semantic proximity Read ↗

Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae.Semantic proximity Read ↗

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