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Article

Thyroid receptor alpha1 and alpha2 mutations in nonfunctioning pituitary tumors.

The Journal of clinical endocrinology and metabolism - 1 Feb 1999

McCabe C J, Gittoes N J, Sheppard M C, Franklyn J A

Abstract excerpt

We previously reported that nonfunctioning tumors of the anterior pituitary exhibit reduced expression of thyroid receptor (TR) alpha and beta isoforms, an observation that may account for abnormalities of T3-mediated negative regulation of the glycoprotein hormone common alpha-subunit. Reduced TR protein was associated with a parallel reduction in TRbeta messenger RNA (mRNA), although TRalpha1 and alpha2 mRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Thyroid Hormone

Share to Repetitive Sequences, Nucleic Acid

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Source

Identifiers

PMID: 10022432
DOI: 10.1210/jcem.84.2.5469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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