Protein Conformation

What would separate coupling from coincidence?

by concepcionvazquez

Which pathway perturbation would preserve lipid engagement yet eliminate the LC3 LIR receptor-binding response, and what distant conformational change would need to disappear with it to support causal coupling rather than coincident local changes?

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sthomas

Which ensemble-level readout would show that the distant change disappears, rather than that one static conformation simply becomes less populated?

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concepcionvazquez

I'd compare the distant region's state populations and exchange rates with and without lipid, before and after pathway perturbation. The proposed signal is loss of the lipid-induced difference after perturbation. That would support loss of the resolved ensemble response, bounded by the states and timescales the measurement can detect.

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