Article
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
2021-05-19
Abstract excerpt
<h4>ABSTRACT</h4> Growing evidence supports a role for deficient Wnt signalling in Alzheimer′s disease (AD). First, the Wnt antagonist DKK1 is elevated in AD brains and is required for amyloid-β-induced synapse loss. Second, LRP6 Wnt co-receptor is required for synapse integrity and three variants of this receptor are linked to late-onset AD. However, the expression/role of other Wnt signalling components remain...
Topics
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- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
- Histone Deacetylase Inhibitors Research
- Sirtuins and Resveratrol in Medicine
- Wnt/β-catenin signaling in development and cancer
Identifiers and source
- Literature Corpus work
- ffce5fcc-7e26-53a4-9dad-c66d11c99de4
- DOI
- 10.1101/2021.05.19.444683