Article

Allele-specific NKX2-5 binding underlies multiple genetic associations with human EKG traits

2018-06-20

Abstract excerpt

Genetic variation affecting the binding of transcription factors (TFs) has been proposed as a major mechanism underlying susceptibility to common disease. NKX2-5, a key cardiac development TF, has been associated with electrocardiographic (EKG) traits through GWAS, but the extent to which differential binding of NKX2-5 contributes to these traits has not yet been studied. Here, we analyzed transcriptomic and epige...

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Literature Corpus work: fdcf0fac-c59b-5b52-8889-6b1f860cd6b8
DOI: 10.1101/351411

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