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Inactivation of PI3K/Akt pathway and upregulation of PTEN gene are involved in daucosterol, isolated from Salvia sahendica, induced apoptosis in human breast adenocarcinoma cells

2014-07-01

Abstract excerpt

Salvia sahendica has been traditionally used for antibacterial, anti-fungal, and anti-cancer purposes and treatment of dyspepsia in many parts of Iran.Our aim was to investigate the mechanism by which daucosterol a β-sitosterol glycoside isolated from S. sahendica induced apoptosis against human breast adenocarcinoma MCF-7 cells.MCF-7 cells were treated with 5, 10, 20 and 40μM of daucosterol for 24h, and prolifera...

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Literature Corpus work
fd620afa-80fa-5802-b959-0ee155829d34
DOI
10.1016/j.sajb.2014.03.010
Open publication

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Inactivation of PI3K/Akt pathway and upregulation of PTEN gene are involved in daucosterol, isolated from Salvia sahendica, induced apoptosis in human breast adenocarcinoma cellsDOI 10.1016/j.sajb.2014.03.010
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