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Article

A novel role of the Batten disease gene CLN3: association with BMP synthesis.

Biochemical and biophysical research communications - 22 Jun 2007

Hobert Judith A, Dawson Glyn

Abstract excerpt

Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) results from a deficiency of CLN3, a protein recently identified within detergent-resistant membranes (DRMs). To study the function of CLN3 within these domains we isolated DRMs from control and JNCL-brain and noted that JNCL-derived DRMs are less buoyant than control. Analysis of DRM phospholipids derived from JNCL-brain revealed a reduction of...

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Source

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Identifiers

PMID: 17482562
DOI: 10.1016/j.bbrc.2007.04.064
PMCID: PMC2720048

Genes

CLN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel role of the Batten disease gene CLN3: association with BMP synthesis.PMID 17482562Read ↗

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CLN3 deficiency leads to neurological and metabolic perturbations during early developmentSemantic proximity Read ↗

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Current Insights in Elucidation of Possible Molecular Mechanisms of the Juvenile Form of Batten Disease.Semantic proximity Read ↗

CLN3p impacts galactosylceramide transport, raft morphology, and lipid content.Semantic proximity Read ↗

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Loss of Cln3 function in the social amoeba Dictyostelium discoideum causes pleiotropic effects that are rescued by human CLN3.Semantic proximity Read ↗

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