Article

Long non-coding RNA TUG1 is down-regulated in Friedreich’s ataxia

2023-09-25

Abstract excerpt

Friedreich’s Ataxia (FRDA) is a neurodegenerative disorder caused by reduced frataxin (FXN) levels. It leads to motor and sensory impairments and has a median life expectancy of around 35 years. As the most common inherited form of ataxia with no cure, FRDA lacks reliable, non-invasive biomarkers, prolonging and inflating the cost of clinical trials. This study identifies long non-coding RNA Tug1 as a potential bl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd0f29db-a18d-5fbc-b861-513b425ee447
DOI: 10.1101/2023.09.22.558879

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Long non-coding RNA TUG1 is down-regulated in Friedreich’s ataxiaDOI 10.1101/2023.09.22.558879Read

Beyond loss of frataxin: the complex molecular pathology of Friedreich ataxia.Semantic proximity Read

Friedreich ataxia transcriptomic dysregulation and identification of cell type-specific biomarkers: A systematic review and meta-analysisSemantic proximity Read

A combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design.Semantic proximity Read

Inducible and reversible phenotypes in a novel mouse model of Friedreich’s AtaxiaSemantic proximity Read

From Genetic Mutation to Therapy in Friedreich Ataxia: Molecular Mechanisms, Therapeutic Advances, and Translational ChallengesSemantic proximity Read

Friedreich's ataxia: new insightsSemantic proximity Read

A gene expression phenotype in lymphocytes from Friedreich ataxia patients.Semantic proximity Read

Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration.Semantic proximity Read

Development of Frataxin Gene Expression Measures for the Evaluation of Experimental Treatments in Friedreich’s AtaxiaSemantic proximity Read

Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.Semantic proximity Read

A new FRDA mouse model [Fxnnull:YG8s(GAA) > 800] with more than 800 GAA repeatsSemantic proximity Read

Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC‐neurons and cardiomyocytesSemantic proximity Read