Back to search

Article

A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses

2021-03-18

Abstract excerpt

The standard dosing of the Pfizer/BioNTech BNT162b2 mRNA vaccine validated in clinical trials includes two doses administered three weeks apart. While the decision by some public health authorities to space the doses because of limiting supply has raised concerns about vaccine efficacy, data indicate that a single dose is up to 90% effective starting 14 days after its administration. We analyzed humoral and T cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fca944cf-fc92-589f-a0e5-2ecb25519444
DOI
10.1101/2021.03.18.435972
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responsesDOI 10.1101/2021.03.18.435972
Waning and boosting of functional humoral immunity to SARS-CoV-2Semantic proximity
BNT162b2 induced neutralizing and non-neutralizing antibody functions against SARSCoV-2 diminish with ageSemantic proximity
Class switch toward IgG2 and IgG4 is more pronounced in BNT162b2 compared to mRNA-1273 COVID-19 vaccineesSemantic proximity
Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.SSemantic proximity
Waning and boosting of antibody Fc-effector functions upon SARS-CoV-2 vaccinationSemantic proximity
Neutralizing antibodies to SARS‐CoV‐2 variants of concern including Delta and Omicron in subjects receiving mRNA‐1273, BNT162b2, and Ad26.COV2.S vaccinesSemantic proximity
mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concernSemantic proximity
Resilient Fc-Effector Functions Across SARS-CoV-2 Variants of Concern Following mRNA-1273 VaccinationSemantic proximity
Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and - experienced subjectsSemantic proximity
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functionsSemantic proximity
Comprehensive assessment of humoral response after Pfizer BNT162b2 mRNA Covid-19 vaccination: a three-case seriesSemantic proximity
Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variantsSemantic proximity
Select a neighboring publication to make it the new centre.