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Article

Frequent mutations in HLA and related genes in extranodal NK/T cell lymphomas.

Leukemia & lymphoma - 1 Jan 2021

Polprasert Chantana, Takeuchi Yasuhide, Makishima Hideki, Wudhikarn Kitsada, Kakiuchi Nobuyuki, Tangnuntachai Nichthida, Assanasen Thamathorn, Sitthi Wimonmas, Muhamad Hamidah, Lawasut Panisinee, Kongkiatkamon Sunisa, Bunworasate Udomsak, Izutsu Koji, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ogawa Seishi, Yoshida Kenichi, Rojnuckarin Ponlapat

Abstract excerpt

Extranodal NK/T cell lymphomas (ENKTCLs) are aggressive Epstein-Barr virus-associated T/NK neoplasms that predominantly affect Asians. To explore the causative somatic events, we conducted a comprehensive genetic analysis of 19 ENKTCL patients by whole-genome (N = 2), whole-exome (N = 16), and targeted sequencing (N = 15). Commonly deregulated gene pathways in ENKTCLs included epigenetic modifiers (58%, 11/19)...

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Identifiers

PMID: 32964767
DOI: 10.1080/10428194.2020.1821011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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