Article

Eight-year progression of leukoencephalopathy with calcifications and cysts in a patient with Labrune syndrome who underwent multiple surgeries: A case report

2026-04-07

Abstract excerpt

<title>Abstract</title> <p> Background Leukoencephalopathy with intracranial calcifications and cysts (LCC), also known as Labrune syndrome, is a rare genetic microangiopathy caused by biallelic mutations in <italic>SNORD118</italic> . The mechanisms by which loss-of-function mutations in <italic>SNORD118</italic> develop into leukoencephalopathy, calcifications, and intracranial cysts remains unknown. Case...

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Literature Corpus work: fc4ae18a-6d73-5143-ab2c-72792130fcb6
DOI: 10.21203/rs.3.rs-9133567/v1

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