Article

Modeling Osteoclast Defect and Altered Hematopoietic Stem Cell Niche in Osteopetrosis with Patient-Derived iPSCs

2021-03-09

Abstract excerpt

<title>Abstract</title> <p>Background Patients with osteopetrosis present with defective bone resorption caused by the lack of osteoclast activity and hematopoietic alterations, but their bone marrow hematopoietic stem/progenitor cell and osteoclast contents might be different. Osteoclasts recently have been described as the main regulators of HSCs niche, however, their exact role remains controversial due to th...

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Literature Corpus work: fac5b524-6473-59e6-b7a6-a7c29c627cbc
DOI: 10.21203/rs.3.rs-258821/v1

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