Article

Novel drug discovery against breast and lung cancer using pharmacophore based 2H-1-benzopyran-2-one derivative

2022-04-18

Abstract excerpt

With the rising number of cancer patients and the associated cancer resistance pathway, the demand for design of innovative novel drugs has never been greater. Coumarins (2H-1-benzopyran-2-one) are an antibiotic that is effective against a variety of diseases. Breast cancer and lung cancer were the focus of this research. To create a pharmacophore hypothesis, biologically active coumarin derivatives were tested ag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa18ad1a-5372-5385-9050-68e46f466a3a
DOI: 10.21203/rs.3.rs-1541154/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel drug discovery against breast and lung cancer using pharmacophore based 2H-1-benzopyran-2-one derivativeDOI 10.21203/rs.3.rs-1541154/v1Read

Targeting natural compounds against HER2 kinase domain as potential anticancer drugs applying pharmacophore based molecular modelling approachesSemantic proximity Read

Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A ReviewSemantic proximity Read

Structure-based virtual screening, pharmacokinetic prediction, molecular dynamics studies for the identification of novel EGFR inhibitors in breast cancerSemantic proximity Read

Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cellsSemantic proximity Read

Potential Role of Benzoic Acid and its Synthetic Derivatives to Alleviate Cancer: An Up-to-Date ReviewSemantic proximity Read

QSAR-based models for designing quinazoline/imidazothiazoles/pyrazolopyrimidines based inhibitors against wild and mutant EGFR.Semantic proximity Read

Natural Compounds or Their Derivatives against Breast Cancer: A Computational Study.Semantic proximity Read

Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapidaSemantic proximity Read

Virtual screening, XGBoost based QSAR modelling, Molecular Docking and Molecular Dynamics Simulation approach to discover a new inhibitor targeting ErbB1 ProteinSemantic proximity Read

In silico design and molecular docking study of CDK2 inhibitors with potent cytotoxic activity against HCT116 colorectal cancer cell lineSemantic proximity Read

Ligand-based pharmacophore modeling, virtual screening, and 2D quantitative structure-activity relationship performance on anti-Hepatitis B virus flavonolsSemantic proximity Read

Screening and identification of phytochemical drug molecules against mutant BRCA1 receptor of breast cancer using computational approaches.Semantic proximity Read