Article

Genome Sequencing-Based Evolutionary Prediction of Glycan-Adhering Lectins and Experimental Evaluation of a Lectin (FimH) Inhibitor Using an Enterohemorrhagic Escherichia coli Strain Isolated in Korea

2022-04-14

Abstract excerpt

We analyzed the evolutionary characteristics of the predicted lectin-like adhesins to construct a lectin-glycan interaction network (LGI). A total of 20,603 assembled Esherichia. coli sequences were retrieved from NCBI, including 2,240 strains with Shiga toxin in their genome. A strain isolated from a Korean patient with diarrhea, EHEC NCCP14539, was also sequenced. The outer-membrane embedded proteins which could...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9c6bf76-60a9-52bf-bf3a-d5a062e55bf7
DOI: 10.21203/rs.3.rs-1548018/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome Sequencing-Based Evolutionary Prediction of Glycan-Adhering Lectins and Experimental Evaluation of a Lectin (FimH) Inhibitor Using an Enterohemorrhagic Escherichia coli Strain Isolated in KoreaDOI 10.21203/rs.3.rs-1548018/v1Read

Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic <i>E. coli adhesin</i>Semantic proximity Read

Distribution and diversity of glycocin biosynthesis gene clusters beyond FirmicutesSemantic proximity Read

Genomic island-encoded regulatory proteins in enterohemorrhagic Escherichia coli O157:H7Semantic proximity Read

Enterotoxigenic Escherichia coli–blood group A interactions intensify diarrheal severitySemantic proximity Read

ChiA: a major player in the virulence of Crohn’s disease-associated adherent and invasive Escherichia coli (AIEC)Semantic proximity Read

In silico Analyses of Core Proteins and Putative Effector and Immunity Proteins for T6SS in Enterohemorrhagic E. coliSemantic proximity Read

Comparative genomics and phylogenetic analysis of S. dysenteriae subgroup.Semantic proximity Read

Subtractive Genomics Approach for in Silico Identification and Characterization of Novel Drug Targets in Neisseria Meningitides Serogroup BSemantic proximity Read

Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strainsSemantic proximity Read

Divergent modes of glycan recognition by a new family of carbohydrate-binding modules.Semantic proximity Read

Comparative Genomics and Immunoinformatics Approach for the Identification of Vaccine Candidates for Enterohemorrhagic Escherichia coli O157:H7Semantic proximity Read

Lectin-Seq: a method to profile lectin-microbe interactions in native communitiesSemantic proximity Read