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Nontypeable <i>Haemophilus influenzae</i> redox recycling of protein thiols promotes resistance to oxidative killing and bacterial survival in biofilms in a smoke related infection model

2021-08-26

Abstract excerpt

Smoke exposure is a risk factor for community acquired pneumonia, which is typically caused by host adapted opportunists like nontypeable Haemophilus influenzae (NTHi). Genomic analyses of NTHi revealed homologs of enzymes involved in thiol metabolism, which can have key roles in oxidant resistance. Using a clinical NTHi isolate (NTHi 7P49H1), we generated isogenic mutant bacterial strains in which homologs of gl...

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Literature Corpus work
f9be2b13-d393-5871-b250-7e778662c94d
DOI
10.1101/2021.08.25.457736
Open publication

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Nontypeable <i>Haemophilus influenzae</i> redox recycling of protein thiols promotes resistance to oxidative killing and bacterial survival in biofilms in a smoke related infection modelDOI 10.1101/2021.08.25.457736
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