Extracardiac Manifestations Fail to Predict the Severity of Cardiac Phenotype in Children and Young Adults with Marfan Syndrome

Abstract excerpt

<title>Abstract</title> <p>We performed a secondary analysis of the Pediatric Heart Network Marfan Trial public-use database to evaluate associations between extracardiac features and cardiac and aortic phenotypes in study participants. Aortic aneurysm phenotype was defined as aortic root Z-score ≥ 4.5, aortic root growth rate ≥ 75th percentile, aortic dissection, and aortic surgery. Severe cardiac phenotype was...

Topics

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• Aorta
• Aortic Aneurysm
• Datasets as Topic
• Heart
• Marfan Syndrome
• Multicenter Studies as Topic
• Randomized Controlled Trials as Topic
• United States

Identifiers and source

Literature Corpus work

f945a4f5-3045-5527-ac2e-a33c4d93cbc1

DOI

10.21203/rs.3.rs-3994693/v1